A Retrospective Study for Detection of Inducible Resistance to Clindamycin in Staphylococcus aureus Isolates Using D-Test at RIMS Teaching Hospital, Raichur, India
نویسندگان
چکیده
Staphylococci are important causative agents of nosocomial and community acquired infections in skin and soft tissues. Emergence of methicillin resistance in Staphylococci has left us with very few therapeutic alternatives available to treat. The Macrolide – lincosamide Streptogramin B (MLSB) family of antibiotics serves as one such alternative with Clindamycin being preferred agent due to its excellent pharmacokinetic properties. [1] Strains with inducible resistance to Clindamycin are difficult to detect in the routine laboratory test, as they appear erythromycin resistant and Clindamycin sensitive in vitro, when not placed adjacent to each other. In such cases, in-vivo therapy with Clindamycin may select therapeutic failure. [2,
منابع مشابه
فراوانی مقاومت القائی نسبت به کلیندامایسین در استافیلوکوکوس اورئوس و استافیلوکوکوس‌های کواگولاز منفی با استفاده از تست D : یک گزارش کوتاه
Background and Objective: The D-test is performed by placing clindamycin and erythromycin impregnated disks at a standard distance on the agar plate then looking for the flattening of inhibition zone around the clindamycin disk. A positive D-test indicates clindamycin inducible resistance and also predicts treatment failure possibility of this antibiotic in clinic. Prevalence of staphyl...
متن کاملConstitutive and Inducible Clindamycin Resistance Frequencies among Staphylococcus sp. Coagulase Negative Isolates in Al-Basrah Governorate, Iraq
Background: Antibiotics called macrolide, lincosamide and streptogramin B (MLSB) are being used to treat staphylococci infections. Multiple pathways that impart resistance to MLSB antibiotics have been confirmed to cause clinical failure. The present work aimed to determine the frequency of constitutive and inducible clindamycin resistant among coagulase-negative staphylococci (CoNS) isolates o...
متن کاملفراوانی مقاومت القایی به کلیندامایسین و تحلیل پروفایل مقاومت چندگانه آنتی بیوتیکی در استافیلوکوکوس اورئوس مقاوم به متی سیلین
Background and purpose: Clindamycin is used in treatment of common infections caused by methicillin-resistant Staphylococcus aureus (MRSA). Constitutive or inducible resistance of clindamycin are important factors in choosing that as an effective antibiotic. The aims of this study were to determine inducible resistance clindamycin and analysis of multiple antibiotic resistance profile in clinic...
متن کاملاهمیت مقاومت القایی نسبت به کلیندامایسین در ایزوله‌های بالینی استافیلوکوکوس اورئوس واجد ژن انتروتوکسین
Background: Clindamycin is a suitable antibiotic for treatment of skin and soft tissue infections. Moreover, it can suppress toxin production in many pathogenic bacteria such as S. aureus. There are two mechanisms of resistance in this antibiotic. Constitutive resistance can be detected by standard disk diffusion method but in the case of inducible resistance, D-test should be carried out. The ...
متن کاملPrevalence of Macrolide-Lincosamide-Streptogramin B (MLSB) Resistance in S. aureus Isolated from Patients in Tehran, Iran
Background and Objectives: Staphylococcus aureus is an important cause of nosocomial and community-acquired infections in every region of the world. Clindamycin is one of the alternative agents used to treat S. aureus infections and accurate identification of clindamycin resistance is important to prevent therapeutic failure. Unfortunately, inducible clindamycin resistance is ...
متن کامل